解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Anti-Leu 7 antibody reacts with determinants on a subset of natural killer (NK) cells and myelin-associated glycoprotein (MAG). In a patient patient with peripheral neuropathy and IgM autoantibodies against MAG, we found the distribution and functions of NK cells to be normal. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.4.566
更新日期:1986-04-01 00:00:00
abstract::We studied evoked potentials (EPs) in 27 patients with typical acute Guillain-Barré syndrome and 3 with Fisher's syndrome. Three of 21 had BAEP abnormalities: 1 with bilateral I-III, 1 with unilateral I-III, and another with unilateral III-V interwave latency prolongations. Three with Fisher's syndrome had normal BAEP...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.4.587
更新日期:1986-04-01 00:00:00
abstract::In four patients who received periocular injections of botulinum toxin for blepharospasm, abnormal neuromuscular transmission was demonstrated by single-fiber EMG in arm muscles. The time course with which the abnormalities developed and cleared, as well as the inverse relationship between the neuromuscular jitter and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.4.545
更新日期:1986-04-01 00:00:00
abstract::We compared the neurologic and cognitive performance of 15 young veterans who suffered unilateral penetrating missile wounds to the basal forebrain 15 years ago in the Vietnam War with uninjured controls and patients with lesions elsewhere in the brain. The subjects performed worse on tests of episodic memory, reasoni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.4.459
更新日期:1986-04-01 00:00:00
abstract::We observed that patients with amnesia after cardiac arrest had preserved recognition memory despite profound loss of recall memory. In the present study, rate of forgetting was measured in six amnesic subjects for both recall and recognition memory of verbal material. The data show that recall decayed significantly f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.3.408
更新日期:1986-03-01 00:00:00
abstract::We studied 30 necropsy cases of vascular dementia with a lacunar state. Manifestations included dementia, lack of volition, emotional lability, small-stepped gait, dysarthria, urinary incontinence, grasp reflex, pyramidal signs, paraplegia in flexion, and akinetic mutism. Pathologically, there was diffuse incomplete s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.3.340
更新日期:1986-03-01 00:00:00
abstract::In 64 patients with Parkinson's disease (PD), the basal level of prolactin (PRL) was normal. Bromocriptine (BCT) caused a significant suppression of PRL in all parkinsonian patients and controls. When given after BCT treatment, thyrotropin-releasing hormone (TRH) induced a significantly lower PRL rise in recent-onset ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.3.393
更新日期:1986-03-01 00:00:00
abstract::We examined serum-mediated cytotoxicity on cultured rat oligodendrocytes, using serum from patients with acute or chronic progressive multiple sclerosis and normal controls. We found heat-labile serum factors in serum from MS and also in controls. The cytotoxic effects of MS and normal sera were not restored by adding...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.2.276
更新日期:1986-02-01 00:00:00
abstract::Four patients with presumed Tolosa-Hunt syndrome ultimately proved to have a parasellar tumor. All four had manifestations of a cavernous sinus syndrome, normal radiologic and medical investigations, and response to steroid therapy. The Tolosa-Hunt syndrome is a diagnosis of exclusion; many other lesions can simulate ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.2.198
更新日期:1986-02-01 00:00:00
abstract::Valproic acid (VPA) has been postulated to exert its anticonvulsant effects by interaction with the postsynaptic GABA receptor. To test that hypothesis, we applied VPA in clinically appropriate concentrations to cortical neurons in dissociated cell culture. VPA did not enhance the postsynaptic effect of GABA, but did ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.2.259
更新日期:1986-02-01 00:00:00
abstract::Concentrations of cyclic adenosine 3',5' monophosphate (cAMP) were significantly lower in parkinsonian patients than in controls, but concentrations of guanosine 3',5' monophosphate (cGMP) were not altered. Both cAMP and cGMP levels were lower in patients with more severe symptoms on the left side of the body. Somatos...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.1.89
更新日期:1986-01-01 00:00:00
abstract::Seven patients had pendular, vertical, isolated movements of the eyes soon after severe pontine strokes. The movements had a frequency of about 2 Hz and amplitudes of 3 to 40 degrees. Other rhythmic body movements at similar frequencies occurred in four patients after a delay of 6 weeks to 9 months. The character and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.1.86
更新日期:1986-01-01 00:00:00
abstract::Nuclear magnetic resonance (NMR) imaging was superior to CT for imaging the brain lesions of 27 patients with MS. The incidence of abnormal examinations was 78% by NMR and 63% by CT. In cases in which both studies were abnormal, NMR usually demonstrated many more lesions and more extensive involvement than CT. The app...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.1.27
更新日期:1986-01-01 00:00:00
abstract::A marked decrease in the amplitude of the evoked thenar compound muscle action potential followed brief exercise at room temperature in two patients with paramyotonia congenita. This decline was more rapid and pronounced in our patient with coexistent thyrotoxicosis. The prolonged recovery period in paramyotonia conge...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.1.130
更新日期:1986-01-01 00:00:00
abstract::We evaluated the effects of isoniazid on tremor in 13 patients with MS. Patients were evaluated before treatment, after 1 month of therapy (1,000 mg daily), and 1 month after the last dose. Ten patients improved on at least one of three methods of evaluation. Transient side effects were common, possibly because there ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.35.12.1772
更新日期:1985-12-01 00:00:00
abstract::Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity. The only factor that seemed to correlate with seizures was a se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.12.1769
更新日期:1985-12-01 00:00:00
abstract::We have demonstrated the reliability of a noninvasive method for successfully localizing the intracranial origin of the EEG. The dipole localization method (DLM) is a computer-assisted, mathematical method based on electrical field theory and is similar to localization methods currently used by electrocardiologists. I...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.12.1702
更新日期:1985-12-01 00:00:00
abstract::We detected 29 conduction blocks in 12 patients with hereditary neuropathy and liability to pressure palsies. The blocks occurred at entrapment sites, most often the ulnar nerve at the elbow. Some had lasted for several years. This kind of block seems to be characteristic of the neuropathy, and may be related to the l...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.11.1639
更新日期:1985-11-01 00:00:00
abstract::We studied two patients with Meige syndrome who developed alpha-methyldopa-induced parkinsonism. Opposite responses of parkinsonian and dystonic symptoms to antiparkinson drugs in some cases suggest a functionally reciprocal relationship between these disorders. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.11.1668
更新日期:1985-11-01 00:00:00
abstract::Subacute sclerosing panencephalitis (SSPE) is characterized by a hyperimmune state toward the polypeptides of measles virus except the matrix (M) protein. Using cloned (3H)-labeled complementary DNA probes for in situ hybridization, we found the M protein and nucleocapsid (NP) protein nucleotide sequences in glial cel...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.11.1605
更新日期:1985-11-01 00:00:00
abstract::GM1 gangliosidosis is usually a pediatric disease caused by hereditary acid beta-galactosidase deficiency. There have been a few cases in adults. We saw a 51-year-old Japanese man with type 3 GM1 gangliosidosis who was manifesting dementia, dysarthria, gait disturbance, and limb rigidity. Radiologic studies showed pla...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.10.1490
更新日期:1985-10-01 00:00:00
abstract::CSF does not normally contain motile cells within flagella or cilia. When motile cells are seen in the CSF, they may be incorrectly assumed to be amebae. We studied a patient with a traumatic mucocele, in whom motile ciliated respiratory epithelial cells were seen in the CSF and within a frontal lobe brain abscess. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.10.1487
更新日期:1985-10-01 00:00:00
abstract::Guillain-Barré syndrome (GBS) appeared in four patients 1 to 2 weeks after epidural anesthesia. In all patients, clinical diagnosis was confirmed by CSF findings and nerve conduction velocity studies. Although epidural anesthesia has not been listed as an antecedent event in GBS, evidence for the relationship has been...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.10.1473
更新日期:1985-10-01 00:00:00
abstract::Four patients with primary writing tremor had a focal, task-specific tremor that responded to anticholinergic drugs. Physiologic features included EMG activity alternating in antagonist muscles, 5- to 20-microV cerebral potentials evoked by stretch of pronator teres, and no C-reflexes. Another patient had myoclonic je...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.9.1387
更新日期:1985-09-01 00:00:00
abstract::A right-handed woman with independent left- and right-sided temporal lobe discharges was studied by continuous EEG and videotape monitoring for 3 weeks. Changes in affect were noted in the immediate and extended postictal periods and varied with the side of discharge. After a left-sided discharge, she became globally ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.9.1335
更新日期:1985-09-01 00:00:00
abstract::Two women with myasthenia gravis became apneic immediately after IV injection of iodinated contrast material for CT. Aggravation of myasthenia continued for days after this initial reaction. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.8.1219
更新日期:1985-08-01 00:00:00
abstract::Twenty-seven patients with static or worsening chronic inflammatory-demyelinating polyradiculoneuropathy were randomly assigned to alternate day decremental prednisone therapy alone or with azathioprine (2 mg/kg) for 9 months. No statistically significant alterations were demonstrated between these treatment schedules...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.35.8.1173
更新日期:1985-08-01 00:00:00
abstract::Using a radioreceptor technique, we assayed serum trihexyphenidyl levels in patients with dystonia being treated chronically with high dosage. We found a significant correlation between total daily dose and the daily lowest (trough) serum levels. There was no relationship between serum levels and therapeutic response ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.7.1066
更新日期:1985-07-01 00:00:00
abstract::We studied performance on tests of visual neglect and left lateral gaze after caloric stimulation in 18 patients with left-sided visual neglect after strokes. Except for one patient with absent vestibulo-ocular responses, all improved during caloric stimulation on the left by cold (LC) or on the right by warm water (R...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.7.1019
更新日期:1985-07-01 00:00:00
abstract::Progressive thoracic myelopathy occurred in a patient with AIDS. Concurrent opportunistic infections included disseminated systemic cytomegalovirus, aspergillosis, and cutaneous herpes simplex virus (HSV). At autopsy, immune stains indicated that the myelopathy was caused by HSV type 2 infection of the spinal cord. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.7.1071
更新日期:1985-07-01 00:00:00
abstract::We studied 35 patients with nonseptic cardiogenic cerebral emboli. In 28 cases, there was sudden onset with maximal neurologic deficit within 1 hour; in 7 cases, there was progression in 24 hours. In six cases, neurologic abnormality worsened in the first week after an initial period of stabilization. CT showed eviden...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.6.896
更新日期:1985-06-01 00:00:00
abstract::Data from three patients and 22 previously reported cases suggest that cerebral microinfarction causes a recognizable clinical syndrome. All cases present with stroke, followed by progressive dementia and often with visual field deficits, peripheral vascular disease, and signs of motor neuron dysfunction. The average ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.6.789
更新日期:1985-06-01 00:00:00
abstract::A 33-year-old man with untreated hypertension had sudden onset of signs and symptoms suggestive of a dorsal lateral medullary syndrome. He died after 27 days. Postmortem studies revealed intramedullary hemorrhage with extension into the fourth ventricle and hypertensive cardiovascular disease. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.6.925
更新日期:1985-06-01 00:00:00
abstract::Serial determinations of spinal fluid homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were made in four patients with the Lesch-Nyhan syndrome over a 5-year period. Control spinal fluids for age-matched comparison were obtained from 194 neurologic and nonneurologic pediatric patients. A rapid decline i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.6.907
更新日期:1985-06-01 00:00:00
abstract::Data from the Aspirin in Transient Ischemic Attack (AITIA) study, an ongoing study of two platelet antiaggregant drugs, and other published therapeutic trials were reviewed to determine whether the severity of stroke is reduced in patients taking platelet antiaggregants. Data from three of four studies suggest that st...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1212/wnl.35.5.632
更新日期:1985-05-01 00:00:00
abstract::To examine animal exposure in ALS patients, a case-control study was undertaken on 40 ALS patients and 40 closely matched controls. Exposure to pets of any kind and to small dogs in the period from birth until 10 years before onset of ALS symptoms was significantly increased. Affected men showed a trend toward increas...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.5.717
更新日期:1985-05-01 00:00:00
abstract::The incidence of MS in the Orkney Islands has been updated from 1941 to September 21, 1983. Since 1965, MS incidence rates have fallen significantly when compared with those for 1941 to 1964. Alterations in age-specific prevalence, mean duration of illness, and mean age of the MS population are consistent with the dec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.4.545
更新日期:1985-04-01 00:00:00
abstract::We found an antinuclear antibody highly restricted to nuclei of neurons in two patients with subacute sensory neuronopathy complicating oat cell carcinoma of the lung. Serum was tested by indirect immunofluorescence and immunoperoxidase staining. At low concentrations of antibody, only the nuclei of the neurons were s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.4.538
更新日期:1985-04-01 00:00:00
abstract::Several drugs that inhibit the effects of serotonin may reduce or prevent experimental CNS ischemic damage, but these drugs are not approved for human use in the United States. Administration of cyproheptadine (which is available for clinical use) 15 minutes before or 5 minutes after the onset increased the duration o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.4.584
更新日期:1985-04-01 00:00:00
abstract::A 20-year-old woman using an oral diet aid preparation containing phenylpropanolamine presented with an intracerebral hemorrhage and angiographic evidence of cerebral vasculitis. Gas chromatography demonstrated phenylpropanolamine in the urine. Even when used within recommended guidelines, phenylpropanolamine usage sh...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.3.405
更新日期:1985-03-01 00:00:00